慢性肾衰患者血浆脂蛋白相关磷脂酶A2与动脉粥样硬化的关系

目的研究慢性肾功能衰竭患者血浆脂蛋白相关磷脂酶A2(Lp-PLA2)水平与动脉粥样硬化的关系。方法选择慢性肾功能衰竭患者100例和健康对照40例采用酶联免疫吸附(ELISA)法测定血浆脂蛋白相关磷脂酶A2水平,超声技术检测颈动脉内膜中膜厚度和粥样硬化斑块。比较慢性肾衰患者与对照组血浆Lp-PLA2水平及慢性肾功能衰竭患者不同分组间Lp-PLA2水平,并对影响颈动脉颈动脉内膜中膜厚度的多因素进行逐步回归分析。结果慢性肾功能衰竭患者血浆Lp-PLA2水平明显高于健康对照组(232.16±59.36μg/L比129.47±29.72μg/L,P<0.01);透析者血浆Lp-PLA2水平明显高于未透析者(261.84±50.82μg/L比204.73±53.95μg/L,P<0.01);未透析者血浆Lp-PLA2水平与内生肌酐清除率呈负相关(r=-0.567,P<0.01)。有颈动脉粥样斑块者血浆Lp-PLA2水平明显高于无动脉粥样斑块者(281.33±39.72μg/L比188.46±35.02μg/L,P<0.01)。多因素逐步回归分析均显示血浆Lp-PLA2水平与颈动脉内膜中膜厚度呈正相关(β=0.735,P<...

The Role of Lipoprotein-associated Phospholipase A2 on Atherosclerosis in Patients with Chronic Renal Failure

Aim To investigate whether atherosclerosis may be accelerated by lipoprotein-associated phospholipase A2(Lp-PLA2) in patients with chronic renal failure(CRF). Methods 100 patients of CRF and 40 healthy volunteers were involved in the study.The levels of plasma Lp-PLA2 were determined by enzyme-linked immunosorbent assay(ELISA).Intima-middle thickness(IMT) and prevalence atherosclerotic plaques of the extrcranial common carotid artery were measured by high-resolution B-mode ultrasonography. The CRF group lev...