广州地区严重急性呼吸综合征170例临床特点分析

目的探讨当前流行的严重急性呼吸综合征(SARS)的流行病学临床表现、血常规及X线表现等特点.方法回顾性分析该院于2003年2～4月收治的170例SARS的临床资料.结果170例SARS患者的年龄2～89岁,平均(41.2±18.1)岁.男72例,女98例.该病的潜伏期为2～14 d,平均(7.1±3.9)d.主要临床表现有发热(100%)、咳嗽(55.3%)、乏力(21.8%)、气促(能.2%)、腹泻(7.1%)、头痛(24.7%)、肌肉酸痛(33.5%);热程多为3～23d,平均热程(9.4±3.7)d;外周血白细胞正常(71.8%),降低(22.4%),淋巴细胞计数减少者占(24.7%),嗜酸性粒细胞(EOS)降低(83.8%);全部患者均有胸片影像学改变.治疗以综合治疗为主,对症支持治疗,经验性使用抗生素、糖皮质激素对改善中毒症状、阻止病情有一定疗效.结论SARS有强传染性,发热、咳嗽、胸片示肺部炎症表现,外周血白细胞正常式降低,淋巴细胞降低,嗜酸粒细胞降低为主要表现.

Clinical characteristics of the server acute respiratory syndrome in Guangzhou

Objective To explore the information on the clinical features of pafienfs with severe acute respiratory syndrom ( SARS) prevalent recently.Methods Clinical data from 170 patients with SARS admitted during February to April were retrospectively analyzed.Results The patients ranged from 1 to 89 years old,with an average of 41.2+ 18.1. 72 patients were men. The incubation period ranged from 2 to 16 days (mean periods 7.1 +3.9 days ) .The most commmom symptoms included fever (100%), cough (55.3%), malaise (21.8%) , shortness of breath(48.1%),diairrhea ( 6.28 % ) .headache (24.7%) , myalia(33.5%) ; The of fever period ranged from 3 to 23 days , with an average of 9.4 days. 30.6% were diagnosed as severe type of SARS.Peripheral vein blood test showed normal leukocyte(77.8%) ,leukopenia(22.4%) .Other common findings were lymphopenia(in 24.7% of the patients) , decreased EOS(83.8% ) .Infiltrates on chest radiography was seen in all the patients. General combinationtherapy was taken for treating the patients. Emprical therapy most commonly usedincluded antibonics and ami - viral reagents. Glucocorticoid was useful for improving viremia and preventing disease progress and fibrosis of the lungs. Conclusion SARS appears to be highly infectious. Fever followed by rapidly progressive respiratory compromise is the key complex of signs and symptoms from'which the syndrome devices its name.