PCI术后再狭窄的病理生理及其危险因素

经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)是一种成熟的冠心病治疗方法,可以很好的实现血运重建,显著的改善患者的生活质量,降低病残率以及死亡率.然而,PCI使患者受益的同时,也会造成血管再狭窄,虽然术后强效抗血小板药物以及药物洗脱支架的引入一定程度上降低了支架植入术后的再狭窄率,但其所致的晚期支架内血栓形成和再狭窄仍然不能忽视.因此,深入了解PCI术后再狭窄及相关影响因素将为PCI术后并发症的治疗提供新的思路和策略.

Pathphysiology and Risk Factors of Restenosis After Percutaneous Coronary Intervention

Percutaneous coronary intervention (PCI) is a mature therapeutic option in the treatment of coronary heart disease, which have significantly improved myocardial perfusion, the quality of life and reduced morbidity and mortality in patients with ischemic heart diseases in recent years. However, PCI can not only bring benefits to patients, but also cause irreversible mechanical damage of the intimal, eventually resulting in endothelial damage and restenosis of the target vessel. Although the strong effects of antiplatelet drugs and drug-eluting stent postoperative can reduce the rate of restenosis after stent implantation, late stent thrombosis and restenosis still can not be ignored. Adverse cardiac events after PCI continue to be problematic despite advances in stent design and adjunctive pharmacotherapy.The elucidation of the mechanism of PCI associated vascular injury may help to develop an effective treatment modality to manage the complications associated with PCI.