| 动脉粥样硬化的表观遗传学研究进展 |
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| 引用本文： | 刘艳辉 综述,危当恒 审校. 动脉粥样硬化的表观遗传学研究进展[J]. 中国动脉硬化杂志, 2013, 21(4): 369-374 |
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| 作者姓名： | 刘艳辉 综述 危当恒 审校 |
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| 作者单位： | 南华大学心血管疾病研究所,动脉硬化湖南省重点实验室,湖南省衡阳市421001 |
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| 基金项目： | 国家自然科学基金(项目编号：30800449),南华大学高层次人才启动基金 |
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| 摘 要： | 动脉粥样硬化是环境因素与遗传因素相互作用所致的慢性炎症疾病.表观遗传修饰可能是链接环境因素与遗传因素的桥梁,深入了解表观遗传修饰如DNA甲基化、组蛋白修饰以及微小RNA对动脉粥样硬化形成和发展的影响及其作用机制,将进一步阐明动脉粥样硬化的发病机制.并且由于表观遗传修饰可逆,这可能为动脉粥样硬化的治疗提供新的策略和靶点.
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| 关 键 词： | 动脉粥样硬化 表观遗传 DNA甲基化 组蛋白修饰 微小RNA |
| 收稿时间： | 2012-12-03 |
Epigenetic Genetics Research Progress of Atherosclerosis |
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| LIU Yan-Hui,and WEI Dang-Heng. Epigenetic Genetics Research Progress of Atherosclerosis[J]. Chinese Journal of Arteriosclerosis, 2013, 21(4): 369-374 |
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| Authors: | LIU Yan-Hui and WEI Dang-Heng |
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| Affiliation: | (Institute of Cardiovascular Disease,Key Laboratory for Atherosclerology of Hunan Province,University of South China,Hengyang,Hunan 421001,China) |
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| Abstract: | Atherosclerosis is a chronic inflammation disease, which is determined by the interaction of environment factors and genetic factors. Epigenetic modification may be the bridge to link environment factors and genetic factors which contribute to the formation and progression of atherosclerosis. The deeper-knowledge of epigenetic modification such as DNA methylation, histone modification and micro RNA in atherosclerosis may further explore the mechanisms of atherosclerosis. Moreover, epigenetic modification is reversible, which may provide new therapeutic strategies and targets for atherosclerosis. |
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| Keywords: | Atherosclerosis Epigenetic DNA Methylation Histone Modification Micro RNA |
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