| 过氧钒烟酸对糖尿病鼠苯丙氨酸羟化酶活性的影响 |
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| 引用本文： | 王艳林,余斌杰,黎宗保. 过氧钒烟酸对糖尿病鼠苯丙氨酸羟化酶活性的影响[J]. 中华内分泌代谢杂志, 1998, 14(2): 123-125 |
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| 作者姓名： | 王艳林 余斌杰 黎宗保 |
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| 作者单位： | 中山医科大学附属第一医院内分泌研究室!510080(王艳林，余斌杰)，中山医科大学附属第一医院内分泌研究室!510080(黎宗保)，中山医科大学附属第一医院!510080(何哲明)，中山医科大学附属第一医院!510080(胡少眉) |
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| 基金项目： | 广东省自然科学基金，博士后科研基金 |
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| 摘 要： | 目的 探讨过氧钒烟酸（ Ｐ Ｏ Ｖ） 的降血糖作用的分子生物学机制。方法 选用 Ｓ Ｄ 大鼠用链脲佐菌素诱导产生糖尿病鼠动物模型，观察用 Ｐ Ｏ Ｖ 和美迪康（ Ｍｅｔ） 治疗后各组大鼠血、尿糖水平及血肝细胞质中苯丙氨酸羟化酶（ Ｐ Ａ Ｈ） 活性改变情况，并进行比较。结果 糖尿病鼠 Ｐ Ａ Ｈ 活性明显增高，用 Ｐ Ｏ Ｖ治疗４ 周后活性受到抑制，血糖水平明显下降，临床症状得以改善。结论 Ｐ Ｏ Ｖ 的降糖作用优于美迪康，且未见明显毒副作用。
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| 关 键 词： | 过氧钒烟酸 糖尿病 苯丙氨酸羟化酶 |
Effect of peroxovanadate nicotinic acid on phenylalanine hydroxylase activity in diabetic rats |
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| Wang Yanlin,Yu Binjie,Li Zongbao,et al.. Effect of peroxovanadate nicotinic acid on phenylalanine hydroxylase activity in diabetic rats[J]. Chinese Journal of Endocrinology and Metabolism, 1998, 14(2): 123-125 |
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| Authors: | Wang Yanlin Yu Binjie Li Zongbao et al. |
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| Affiliation: | Wang Yanlin,Yu Binjie,Li Zongbao,et al. The First Affiliated Hospital of Sun Yan Sen University of Medical Sciences,510080 |
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| Abstract: | Objective To investigate into the molecular biological mechanism of hypoglycemic effect ofperoxovanadate nicotinic acid ( P O V) on diabetic rats . Methods The streptozotocin induced diabetic S Drats wereselected as the animal model. The blood and urine glucose levels as well as liver plasma phenylalanine hydroxylase( P A H) activity were observed in all groups of rats after P O Vand metformin treatment . Results P A Hactivity inthe diabetic rats was obviously increased . After P O V treatment for 4 weeks , P A H activity was inhibited , bloodglucose levelis decreased markedly and the clinical sym ptoms were im proved . Conclusion The P O V had bettereffectthan m etformin in decreasing hyperglycemia and side effects had not been observed . |
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| Keywords: | Peroxovanadate nicotinic acid Diabetes Phenylalanine hydroxylase |
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