| 地塞米松对先天性膈疝胎鼠肺发育的影响 |
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| 引用本文： | 唐志贤,余家康,王风华,曾荣新,邹焱,李瑞琼,贾炜,夏慧敏. 地塞米松对先天性膈疝胎鼠肺发育的影响[J]. 临床小儿外科杂志, 2008, 7(1): 23-26 |
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| 作者姓名： | 唐志贤 余家康 王风华 曾荣新 邹焱 李瑞琼 贾炜 夏慧敏 |
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| 作者单位： | 广州儿童医院外科,510120;广州儿童医院外科,510120;广州儿童医院外科,510120;广州儿童医院外科,510120;广州儿童医院外科,510120;广州儿童医院外科,510120;广州儿童医院外科,510120;广州儿童医院外科,510120 |
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| 摘 要： | 目的研究地塞米松对先天性膈疝(Congenital Diaphragmatic Hernia,CDH)胎鼠肺发育的影响,并探讨其可能机制。方法采用Nitrofen法制作胎鼠CDH模型并分组,地塞米松组予以产前地塞米松治疗,Nitrofen组则不予地塞米松治疗,另取正常胎鼠为对照组;采用组织学检查方法评价肺发育情况,免疫组化和图像分析方法检测地塞米松作用前后胰岛素样生长因子-Ⅰ(Insulin-like Growth Factor,IGF-Ⅰ)在胎肺中的表达及相对含量。结果与Nitrofen组相比,地塞米松组肺组织中IGF-Ⅰ的表达明显降低,且肺组织发育明显改善。结论胎儿期地塞米松通过下调肺组织中IGF-Ⅰ的表达,来改善肺组织的发育。
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| 关 键 词： | 疝 横膈 胰岛素样生长因子Ⅰ/分析 疾病模型 动物 地塞米松/药理学 大鼠 |
Effect of the Antenatal administration Dexamethasone on the lung development |
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| TANG Zhi-xian,YU Jia-kang,WANG Feng-hua,et al.. Effect of the Antenatal administration Dexamethasone on the lung development[J]. Journal of Clinical Pediatric Surgery, 2008, 7(1): 23-26 |
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| Authors: | TANG Zhi-xian YU Jia-kang WANG Feng-hua et al. |
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| Affiliation: | TANG Zhi-xian,YU Jia-kang,WANG Feng-hua,et al. Department of surgery,Children's Hospital of Guangzhou,Guangzhou,518000,China. |
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| Abstract: | Objective To observe the effects of the antenatal administration of dexamethasone on the fetal lung development in congenital diaphragmatic hernia (CDH) rat model and to investigate its role in the pathogenesis of the pulmonary hypoplasia. Methods The CDH rat model was constructed by using Nitrofen. The animals in the DXE group were treated by the antenatal administration of dexamethasone and the NIT group were not, and the normal fetal rats were used as normal control. The fetal lung development was evalua... |
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| Keywords: | Hernia Diaphragmatic Insulin-Like Growth Factor I/AN Disease Models Animal Dexamethasone/PD Rats |
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