| 青风藤提取物聚乳酸缓释微球的制备及体外释药性能的研究 |
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| 引用本文： | 张雯,张兴祥.青风藤提取物聚乳酸缓释微球的制备及体外释药性能的研究[J].中国中药杂志,2010,35(16):2142-2145. |
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| 作者姓名： | 张雯 张兴祥 |
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| 作者单位： | 天津工业大学,功能纤维研究所,改性与功能纤维天津市重点实验室,天津,300160 |
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| 摘 要： | 目的:制备含青风藤总生物碱提取物的聚乳酸(PLA)微球,并考察其体外释药性能。方法:采用乳化-溶剂挥发法制备青风藤总碱PLA微球,对其形态、包封率、粒径分布进行研究,并探讨了制备条件对PLA微球释药性能的影响。结果:青风藤总碱PLA微球外观圆整,粒径分布均匀,平均包封率和载药量分别为(83.4±5.63)%,(8.7±0.35)%,平均粒径为(21.5±1.22)μm,32 h体外累积释药量为80%。结论:本研究成功制备了青风藤总碱PLA微球;通过控制不同因素,可得到具有良好缓释性能的青风藤总碱PLA微球。
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| 关 键 词： | 青风藤总碱 PLA 微球 缓释 |
| 收稿时间： | 2010/4/22 0:00:00 |
Preparation of sustained release microspheres containing extracts from Caulis sinomenii with polylactic acid and their release property in vitro |
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| ZHAN Wen and ZHANG Xingxiang.Preparation of sustained release microspheres containing extracts from Caulis sinomenii with polylactic acid and their release property in vitro[J].China Journal of Chinese Materia Medica,2010,35(16):2142-2145. |
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| Authors: | ZHAN Wen and ZHANG Xingxiang |
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| Institution: | Institute of Functional Fibers, Tianjin Municipal Key Laboratory of Fiber Modification and Functional Fibers, Tianjin Polytechnic University, Tianjin 300160, China;Institute of Functional Fibers, Tianjin Municipal Key Laboratory of Fiber Modification and Functional Fibers, Tianjin Polytechnic University, Tianjin 300160, China |
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| Abstract: | |
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| Keywords: | total alkaloid extracts of Caulis sinomenii PLA microspheres sustained-release |
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