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Osteopontin overexpression predicts poor prognosis of upper urinary tract urothelial carcinoma
Authors:Hung-Lung Ke MD  MS  Lin-Li Chang PhD  Sheau-Fang Yang MD  Hui-Hui Lin BS  Ching-Chia Li MD  Deng-Chyang Wu MD  PhD  Wen-Jeng Wu MD  PhD
Institution:aDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;bGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;cDepartment of Microbiology, Kaohsiung Medical University, Kaohsiung, Taiwan;dDepartment of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;eDepartment of Urology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;fDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;gDepartment of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Abstract:

Objectives

Studies indicate overexpression of osteopontin (OPN) promotes carcinogenesis, progression and metastasis of multiple human malignancies. However, the function of OPN in urothelial carcinoma (UC) of the upper urinary tract has not been investigated. This study evaluates the clinical significance of OPN expression in upper urinary tract UC.

Materials and methods

One hundred and ten cases (median age = 64, range = 24–84 years) of renal pelvic or ureter UC were retrospectively reviewed in this study. OPN expression were evaluated by immunohistochemistry staining on paraffin-embedded section of the tumor and scored by two qualified pathologists.

Results

High OPN expression was found in 54 (49.1%) of the cancer specimens. OPN expression was not significantly correlated with tumor T stage (P = 0.761), N stage (P = 0.339) or grade (P = 0.349). However, OPN expression was differently expressed by gender (P = 0.012) and cancer location (P = 0.026). OPN expression did not correlate with bladder recurrence-free (P = 0.661) or extra-bladder recurrence-free (P = 0.787) survival, but high OPN expression was a significant predictor for cancer-specific survival (P = 0.014).

Conclusion

Our findings indicated that higher OPN expression is a potential biomarker to predict patient survival. Further study is necessary to investigate the role of OPN in the carcinogenesis of upper urinary tract UC.
Keywords:Osteopontin  Urothelial carcinoma  Ureter cancer  Renal pelvis cancer  Prognosis
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