芜菁还阳参中倍半萜类成分的分离和鉴定

目的　对芜菁还阳参(Crepis napifera (Franch) Babc.)根的化学成分进行研究。方法　采用溶剂分配及各种色谱方法进行分离纯化。得到2个化合物,用¹HNMR,¹³CNMR,DEPT,¹H-¹H COSY,HMQC,HMBC,ROESY,MS和UV光谱技术进行鉴定。结果　得到2个萜类化合物,分别是Δ^4,9-二烯-重排桉烷-13，15-二羧酸-15-β-D-葡糖苷，命名为还阳参酸苷(napiferoside, I)和蒲公英醋酸酯(acetate taraxasterol, II)。结论　化合物I为一新的重排桉烷型倍半萜苷类化合物。

ISOLATION AND IDENTIFICATION OF SESQUITERPENES FROM CREPIS NAPIFERA

AIM　In order to obtain active compounds of the roots of Crepis napifera (Franch) Babc (Compositea), its chemical constituents were studied. METHODS　Solvent partition and gel column chromatography, recrystalization and spectrum were used to extract, isolate and identity the constituents. RESULTS　One sesquiterpene (I) and one triterpene (II) were obtained. (I) and (II) were elucidated as Δ^4,9-dien-eudesmine-13,15-dicarboxylic acid-15-β-D-glucopyranoside (I) and acetate taraxasterol (II) respectively, based on ¹HNMR, ¹³CNMR, ¹H-¹H COSY, HMBC, ROESY, MS and IR spectroscopic data and literature data. CONCLUSION　Compound I is a new eudesmane sesquiterpene glycoside named as napiferosied.