| 黄芪四物汤颗粒剂中黄芪甲苷的含量测定 |
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| 引用本文： | 王贵发,黄萍,马珂. 黄芪四物汤颗粒剂中黄芪甲苷的含量测定[J]. 医药导报, 2003, 22(7): 470-471 |
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| 作者姓名： | 王贵发 黄萍 马珂 |
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| 作者单位： | 1. 浙江省人民医院药剂科,杭州,310014
2. 浙江省立同德医院药剂科,杭州,310012 |
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| 摘 要： | 目的:为黄芪四物汤颗粒剂中黄芪的含量测定建立质控标准.方法:用高效液相色谱法(HPLC)进行检测.条件:hypersilODS C18 (4.0 mm×250 mm,5 μm) 色谱柱,乙腈∶水(31∶69)为流动相,检测波长为203 nm.结果:线性范围0.01～0.20 mg•mL 1,回归方程Y＝0.299 2X＋0.575 7,r＝0.999 8,平均回收率97.9%,RSD为1.0%(n＝5).结论:高效液相色谱法可以快速准确地测定黄芪四物汤颗粒剂中黄芪甲苷的含量.
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| 关 键 词： | 黄芪甲苷 黄芪四物汤颗粒剂 高效液相色谱法 |
| 文章编号： | 1004-0781(2003)07-0470-02 |
| 修稿时间： | 2002-10-18 |
Determination of Astragaloside Ⅳ in Huangqisiwutang Granules |
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| WANG Gui-fa,HUANG Ping,MA Ke. Determination of Astragaloside Ⅳ in Huangqisiwutang Granules[J]. Herald of Medicine, 2003, 22(7): 470-471 |
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| Authors: | WANG Gui-fa HUANG Ping MA Ke |
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| Abstract: | Objective:To determine the content of astragaloside IV in huangqisiuwtang granules. Method: Astragaloside IV was detected by high performance liquid chromatography(HPLC). HPLC conditions: HypersilODS Cm 5 jum(4.0 mm x 250 mm)5um column: acetonitrile: water(31:69) as mobile phase, UV detector at 203 nm. Results:The linear range is 0.01 - 0.20 tng-mL-1 ( F = 0.299 2X+ 0.575 7, r = 0.9998), the average rate of recovery is 97.9% . RSD = 1.0%(n=5) . Conclusion: This method can determine the content of astragaloside IV in huangqisiwutang granules quickly and exactly. |
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| Keywords: | Astragaloside IV Huangqisiwutang granules High performance liquid chromatography |
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