Vasoactive intestinal peptide receptor localization in rat forebrain by autoradiography |
| |
| Authors: | E B De Souza H Seifert M J Kuhar |
| |
| Affiliation: | 1. Department of Neurosciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 U.S.A.;2. Department of Pharmacology and Experimental Therapeutics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 U.S.A.;3. Department of Psychiatry and the Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 U.S.A.;4. Department of Internal Medicine, University of Göttingen, 34 Göttingen F.R.G. |
| |
| Abstract: | Vasoactive intestinal peptide (VIP) receptors were localized in rat forebrain by in vitro labeling light microscopic autoradiography with 125I-labeled VIP. Binding sites for VIP were found in discrete areas of rat forebrain including lamina I of the neocortex and pyriform cortex, caudate-putamen, the hippocampus and molecular layer of the dentate gyrus, basolateral nucleus of the amygdala, several thalamic nuclei and the magnocellular paraventricular and supraoptic nuclei of the hypothalamus. These results are consistent with earlier findings on the immunohistochemical distribution and proposed sites of action of VIP, and reinforce the concept that endogenous VIP may function as a neuromodulator in brain. |
| |
| Keywords: | vasoactive intestinal peptide receptor binding autoradiography gastrointestinal hormones hypothalamus hippocampus cerebral cortex |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
