| 缺氧诱导因子1和Survivin蛋白在食管鳞癌中的表达及其意义 |
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| 引用本文： | 齐洛生,王怀志,王彦威.缺氧诱导因子1和Survivin蛋白在食管鳞癌中的表达及其意义[J].中国误诊学杂志,2008,8(30):7313-7315. |
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| 作者姓名： | 齐洛生 王怀志 王彦威 |
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| 作者单位： | 武警河南总队医院,河南,郑州,450052 |
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| 摘 要： | 目的：探讨缺氧诱导因子1（HIF-1α）和Survivin蛋白表达与食管癌浸润及转移预后生物学行为的关系。方法：应用免疫组化SP法检测37例食管癌中HIF-1α和Survivin蛋白的表达。结果：从正常上皮组织、轻度不典型增生组织、重度不典型增生组织到原位癌、浸润癌，HIF-1α和Survivin蛋白表达的阳性率呈逐渐增高趋势，差异均有显著性（P〈0．05）。结论：HIF-1α与Survivin蛋白可作为判断食管癌生物学行为的客观指标，对判断食管癌的预后具有重要意义。
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| 关 键 词： | 转录因子/代谢 微管棚关蛋白质类/代谢 肿瘤蛋白质类/代谢 食管肿瘤/代谢/病理学 癌 鳞状细胞/代谢/病理学 人类 |
Expression and Significance of HIF-1α and Survivin in Esophageal Squamous Cell Carcinoma |
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| QI Luo-sheng,WANG Huai-zhi,WANG Yan-wei.Expression and Significance of HIF-1α and Survivin in Esophageal Squamous Cell Carcinoma[J].Chinese Journal of Misdiagnostics,2008,8(30):7313-7315. |
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| Authors: | QI Luo-sheng WANG Huai-zhi WANG Yan-wei |
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| Institution: | QI Luo-sheng,WANG Huai-zhi,WANG Yah wei (General Hospital of Henan Armed Police, Zhengzhou 450000, China ) |
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| Abstract: | Objeclive：To study the relations between the expressions of HIF -1α and Survivin to cellular invasion and metastasis of human esophageal carcinoma. Methods ：S P methods were used to detect the expressions of HIF-1α and survivin in 37 cases with carcinoma tissues. Results：The positive expression of HIF-1α and Survivin in tumor-adjacent atypical hyperplasia epithilum had a trendof increasing gradually（P〈0.05）. Conclousion：HIF la and Survivn can become a objective target to evaluate the prognosis of esophageal squamous cell carcinoma. |
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