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Synthesis and anti-platelet activity of obovatol derivatives |
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| Authors: | Jae-Hwan Kwak Seul Lee Eun-Seok Park Jin-Kyung In Jiho Song Young Jin Kim Nam Song Choi Heesoon Lee Yeo-Pyo Yun Jin Tae Hong Young-Shin Kwak Kyung Hoon Min Jae-Kyung Jung |
| Affiliation: | College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 361-763, Korea. |
| Abstract: | Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity. |
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