Effect of lead on the activity of erythrocyte porphobilinogen deaminase in vivo and in vitro |
| |
Authors: | Tomokuni Katsumaro Ichiba Masayoshi |
| |
Institution: | Department of Community Health Science, Saga Medical School, Nabeshima, Saga, Japan |
| |
Abstract: | The effect of lead on the activity of erythrocyte porphobilinogen deaminase (PBGD) in vivo and in vitro was investigated using blood specimens obtained from controls and lead-exposed workers. When lead nitrate was added to the incubation mixture at a final concentration of 10?4 M, 83% inhibition of erythrocyte PBGD activity was found. However, in workers occupationally exposed to lead, no inhibition of erythrocyte PBGD activity was detected. This finding indicates that the erythrocyte PBGD test is not useful for evaluating exposure to lead in workers. In addition, the in vitro study confirmed that mercuric chloride strongly inhibits erythrocyte PBGD activity. |
| |
Keywords: | Lead Erythrocyte Porphobilinogen deaminase Inhibition |
本文献已被 ScienceDirect 等数据库收录! |
|