|
|||||
|
|
The cuprizone model for demyelination |
|
| Authors: | Ø . Torkildsen,L. A. Brunborg,K.-M. Myhr,L. Bø |
| Affiliation: | Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Norway;;Department of Clinical Medicine, Section for Neurology, University of Bergen, Norway;;National Institute of Nutrition and Seafood Research (NIFES), Nordnes, Bergen, Norway |
| Abstract: | Background – Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination. In this model, young mice are fed with the copper chelator cuprizone, leading to oligodendrocyte death and a subsequent reversible demyelination. Spontaneous remyelination can be seen as early as 4 days after withdrawal of cuprizone. Materials and methods – This article reviews previous research on this model and discusses the potential of the model for future application in MS research. Discussion – The cuprizone model correlates with newer histopathological data in MS and is a valuable tool for studies on de- and remyelination. The use of the C57BL/6 strain offers the potential for future studies on transgene and knockout mice. |
| Keywords: | cuprizone demyelination multiple sclerosis |