| 蚯蚓提取物对小鼠肝中荧光产物和血中CAT,GSH-px,SOD含量的影响 |
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| 引用本文： | 张绍章,姚素臣,孙淑芬,李予蓉. 蚯蚓提取物对小鼠肝中荧光产物和血中CAT,GSH-px,SOD含量的影响[J]. 医学争鸣, 1992, 0(1) |
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| 作者姓名： | 张绍章 姚素臣 孙淑芬 李予蓉 |
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| 作者单位： | 第四军医大学放射医学教研室(张绍章)，第四军医大学化学教研室(姚素臣，孙淑芬)，第四军医大学放射医学教研室(李予蓉) |
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| 摘 要： | 作者用比色法同时测定80只正常和80只荷瘤小鼠肝中荧光产物含量和血中CAT,GSH-px,SOD酶活性的变化。结果表明,蚯蚓提取物灌胃后,使正常小鼠肝中荧光产物含量由0.73减至0.60nmol硫酸奎宁/mg组织(P<0.05);血中CAT,GSH-px,SOD酶活性分别由41.99增至47.63μg/mg—Hb(P<0.05),由107.30增至142.78μmol-GSH/ml·min(P<0.05),由14.96增至17.28μg/ml(P<0.01),提示蚯蚓提取物的抑瘤作用机理之一可能与清除自由基有关。
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| 关 键 词： | 蚯蚓提取物 医学 中国传统 荧光产物 过氧化氢酶 谷胱甘肽过氧化物酶 超氧化物歧化酶 |
Effect of earthworm extract on fluorescent products in liver and CAT, GSH-px, SOD content in mouse blood |
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| ZHANG Shao-Zhang,YAO Su-Chen,SUN Shu-Fen and LI Yu-Rong. Effect of earthworm extract on fluorescent products in liver and CAT, GSH-px, SOD content in mouse blood[J]. Negative, 1992, 0(1) |
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| Authors: | ZHANG Shao-Zhang YAO Su-Chen SUN Shu-Fen LI Yu-Rong |
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| Affiliation: | ZHANG Shao-Zhang,YAO Su-Chen,SUN Shu-Fen and LI Yu-Rong Department of Radiation Medicine Department of Chemistry |
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| Abstract: | The present experiment is designed to study the fluorescent products in liver and changes of CAT, GSH-px, SOD content in blood in normal and tumor-bearing mice after earthworm extract administration. The results showed that earthworm extract could reduce the content of fluorescent products in liver and increase CAT, GSH -px, and SOD activity. These findings suggest that the interrelationships among the antitumor drug earthworm extract, the anti-oxidative enzymes and the tumor growth are worthy of study. |
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| Keywords: | earthworm extract medicine Chinese traditional fluorescent products catalase glutathione peroxidase superoxide dismutase |
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