Lamina-specific alteration of C-fibre evoked activity by morphine in the dorsal horn of the rat spinal cord |
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| Authors: | C J Woolf M Fitzgerald |
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| Affiliation: | 1. Department of Physiology, Middlesex Hospital Medical School, Cleveland Street, London W1P 6DB U.K.;1. Cerebral Functions Group, Department of Anatomy, University College London, Gower Street, London WC1E 6BT U.K. |
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| Abstract: | The effect of systemic morphine (5 mg/kg) on the C-fibre evoked activity in the dorsal horn of decerebrate spinalized rats has been investigated. Activity in units recorded from lamina 5 was inhibited in a naloxone-reversible fashion by morphine. However, morphine produced variable changes in the C-evoked activity of units recorded within the substantia gelatinosa, some units showing excitation, some inhibition and some an alteration in the timing and pattern of the C-evoked activity. |
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| Keywords: | To whom correspondence should be addressed. |
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