Expression and significance of nuclear factor kappaB in laryngeal carcinoma] |
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| Authors: | Jiang Zhu Guohua Hu Yucai Sun |
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| Affiliation: | Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. |
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| Abstract: | OBJECTIVE: To explore the expression and significance of NF-kappaB in laryngeal carcinoma. METHOD: The protein expression of NF-kappaB p65 in laryngeal carcinoma tissue and normal laryngeal tissue was examined by Western blot; NF-kappaB DNA binding activity was examined by electrophoretic motility shift assay (EMSA) in 20 laryngeal carcinoma tissue and 12 normal laryngeal tissue. RESULT: The levels of NF-kappaB p65 protein and NF-kappaB DNA binding activity in the laryngeal carcinoma tissue were higher than those in normal laryngeal tissue. CONCLUSION: NF-kappaB may be an important oncoprotein and involves in the occurrence and development of laryngeal carcinoma. |
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