Choroidal thickness outside the laser irradiation area after photodynamic therapy in polypoidal choroidal vasculopathy |
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Authors: | Yukinori Sugano Tomohiro Iida Ichiro Maruko Akira Ojima Tetsuju Sekiryu |
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Affiliation: | 1. Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan 2. Department of Ophthalmology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan
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Abstract: | Purpose To evaluate changes in choroidal thickness adjacent to the area of laser application after photodynamic therapy (PDT) in patients with polypoidal choroidal vasculopathy (PCV) using enhanced depth imaging spectral-domain optical coherence tomography. Methods Masked observers measured the choroidal thickness at the subfovea and superior, inferior and temporal areas adjacent to the area of laser application before, 2 days, 1 week and 1 and 3 months after treatment. Results Thirty-seven patients with PCV treated with PDT with verteporfin were included. The mean subfoveal choroidal thickness decreased significantly (P < 0.001) from 256 ± 115 μm at baseline to 207 ± 111 μm at 3 months; the mean outside choroidal thickness including the superior, inferior and temporal areas decreased significantly (P < 0.001) from 240 ± 92 μm at baseline to 209 ± 86 μm at 3 months. Conclusion PDT affected not only the subfoveal choroid, but also the choroid outside the area of laser application in PCV. |
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