强化戊二醛喷雾剂体外抗菌活性及对乙型肝炎表面抗原的灭活作用试验

目的：考察强化戊二醛喷雾剂体外抗菌活性及对乙型肝炎表面抗原的灭活作用。方法：采用稀释法及反向间接血凝试验法对金葡球菌等７类４８株标准或临床分离的菌株进行体外抗菌活性试验和乙型肝炎表面抗原（ＨＢｓＡｇ）灭活试验。结果：ＭＩＣ和ＭＢＣ几种菌之间呈线性关系，浓度为１．５ｇ／Ｌ的药物，３０ｍｉｎ内即可杀死大部分细菌；强化戊二醛喷雾剂作用１０ｍｉｎ，可完全破坏ＨＢｓＡｇ，其浓度为７．５ｇ／Ｌ。结论：强化戊二醛喷雾剂抗菌活性强大、广谱，特别是对ＨＢｓＡｇ的破坏作用，使其具有其它杀菌消毒剂不可比拟的优势

In vitro antibacterial activity and inactivation of HBsAg study of potentiated glutaral spray

OBJECTIVE:To assess the efficacy of the potentiated glutaral spray for biocidal activity and the inactivation of HBsAg.METHOD:The dilution tests were used for assessing the efficacy of the biocidal activity.The tests were conducted with the following microorganisms(standard strains and/or clinical isolates),Staphylococcus.aureus ATCC 25925,Beta hemolytic streptococci,Escherichia coli ATCC 25922,Klebsiella pneumoniai ATCC 46117,Pseudomonas aesuginosa ATCC 27853,Bacillus cereus and Bacillus subtilis var.Niger.The efficacy of the drug for inactivation of HBsAg was assessed by reverse indirect agglutinate test.RESULTS:Potentiated glutaral spray at a concentration of 1.5 g/L showed that most of the test microorganisms were killed in less than 30 min.And a 7.5 g/L solution could inactivate HBsAg with a 10 min contact time.CONCLUSION:Potentiated glutaral spray is a bactericidal disinfectant which is rapidly effective in combating gram positive and gram negative bacteria.It is also effective against HBsAg.