中华雪胆化学成分研究(Ⅲ)

目的:研究中华雪胆化学成分。方法:应用色谱技术进行分离和纯化,采用UV,IR,MS,NMR等波谱技术鉴定结构。结果:从中华雪胆中分到8个三萜类化合物,分别为23,24-二氢葫芦素B(1),23,24-二氢葫芦素F-25-乙酸酯(2),葫芦素F(3),3-O-(6’-乙酯)-β-D-吡喃葡萄糖醛酸基-齐墩果酸-28-O-α-L-吡喃阿拉伯糖苷(4),齐墩果酸-3-O-(6’-甲酯)-β-D-吡喃葡萄糖醛酸基-(1-3)-α-L-吡喃阿拉伯糖苷(5),齐墩果酸-28-O-β-D-吡喃葡萄糖基(1-6)-β-D-吡喃葡萄糖苷(6),3-O-(6’-甲酯)-β-D-吡喃葡萄糖醛酸基-齐墩果酸-28-O-β-D-吡喃葡萄糖基-(1-6)-β-D-吡喃葡萄糖苷(7),3-O-(6’-甲酯)-β-D-吡喃葡萄糖醛酸基-(1-2)-β-D-吡喃葡萄糖基-齐墩果酸-28-O-β-D-吡喃葡萄糖苷(8)。结论:除化合物2外,其余化合物均是首次从中华雪胆中分离得到。

Chemical components in Hemsleya chensnsis (III)

Objective: To study the chemical constituents of Hemsleya chensnsis.Method: Various chromatographic techniques were used to separate and purify the constituents.The spectral data(MS,NMR) were obtained for structure elucidation.Result: Eight known triterpenoid saponins were isolated from the root of H.chensnsis.Their structures were elucidated as dihydrocucurbitacin B(1),25-O-acetyl-dihydrocucurbitacin F(2),cucurbitacin F(3),3-O-(6′-ethyl ester)-β-D-glucuropyranosyl oleanolic acid-28-O-α-L-arabinopyranoside(4),oleanolic acid-3-(6′-methyl ester)-β-D-glucuropyranosyl(1-3)-α-L-arabinopyranoside(5),oleanolic acid-28-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranoside(6),3-O-(6′-methyl ester)-β-D-glucuropyranosyl oleanolic acid-28-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranoside(7),3-O-(6′-methyl ester)-β-D-glucuropyranosyl(1-2)-β-D-glucopyranoside-oleanolic acid-28-O-β-D-glucopyranoside(8).Conclusion: All compounds except for 2 were isolated from H.chensnsis for the first time.