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| 外用九一丹1个月对家兔血汞、尿汞及肝肾功能的影响 | |
| 引用本文： | 曹玉娥,陈小淼,符胜光,叶媚娜,金惜雯,金若敏,陈红风. 外用九一丹1个月对家兔血汞、尿汞及肝肾功能的影响[J]. 中国中药杂志, 2012, 37(6): 719-722 |
| 作者姓名： | 曹玉娥 陈小淼 符胜光 叶媚娜 金惜雯 金若敏 陈红风 |
| 作者单位： | 1. 上海中医药大学药物安全评价研究中心,上海,201203 2. 上海中医药大学附属龙华医院,上海,200032 3. 上海化工职业病防治院,上海,200041 |
| 基金项目： | 国家"十一五"科技支撑计划项目(2008BAI53B083);浦东新区科技发展基金创新项目(PKJ2008-Y10) |
| 摘 要： | 目的:观察连续给予家兔九一丹(煅石膏-升丹9∶1)1个月后,家兔血汞、尿汞及肝肾功能的变化,以及停药后家兔的恢复情况。方法:将家兔分为2组:煅石膏组及九一丹组;在2组家兔背部一侧,造成面积为5 cm×5 cm创面;于创面处分别给予36 mg煅石膏及40 mg九一丹,4 h后用生理盐水清洗创面。给药前、给药后14,28 d、停药第7,40,71,92天心脏采血检测血汞及肝肾功能指标ALT,AST,CREAT,BUN。停药第1,40,71,92天解剖家兔时从膀胱采集尿液检测尿汞。结果:与煅石膏组比较,九一丹组给药第14,28天以及停药第7,40天血汞浓度均升高(P<0.01);停药第1,40,71天九一丹组尿汞含量升高明显;但对肝肾功能指标未见明显影响。结论:连续1个月给予家兔2倍临床量的九一丹,血汞及尿汞明显升高,但血汞于停药71 d、尿汞于停药3个月可恢复至正常水平,该剂量对家兔肝肾功能指标未产生明显影响。 |
| 关 键 词： | 九一丹 血汞 尿汞 肝肾指标 家兔 外用给药1个月 |
| 收稿时间： | 2012-01-06 |
Effects of external use of Jiuyi Dan for one month on blood and urine mercury levels and liver and kidney functions of rabbits |
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| CAO Yu''e,CHEN Xiaomiao,FU Shengguang,YE Mein,JIN Xiwen,JIN Ruomin and CHEN Hongfeng. Effects of external use of Jiuyi Dan for one month on blood and urine mercury levels and liver and kidney functions of rabbits[J]. China Journal of Chinese Materia Medica, 2012, 37(6): 719-722 | |
| Authors: | CAO Yu''e CHEN Xiaomiao FU Shengguang YE Mein JIN Xiwen JIN Ruomin CHEN Hongfeng |
| Affiliation: | Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;Shanghai Institute of Occupational Disease Prevention, Shanghai 200041, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
| Abstract: | Objective: To observe the changes of the blood and urine mercury(Hg) levels and liver & kidney functions of rabbits after administration of Jiuyi Dan(calcined gypsum-Sheng Dan 9∶1) for 1 month and the recovery of rabbits after the drug withdrawal.Method: The rabbits were randomly divided into 2 groups: the calcined gypsum group and the Jiuyi Dan group.After 36 mg of calcined gypsum and 40 mg of Jiuyi Dan were used on the surface of wound(5 cm×5 cm) on one side of rabbit back for 4 h,the surfaces of wound were washed by saline.The bloods were taken from the rabbit hearts before and after the drug administration for 14 and 28 days,and after the drug withdrawal for 7,40,71,and 92 days for determining Hg level in blood,and liver & kidney function indicators(ALT,AST,CREAT and BUN).The Hg level in urine collected from bladders was examined while rabbits were dissected after the drug withdrawal for 1,40,71,and 92 days.Result: The Hg level in blood was significantly increased(P﹤0.01) after the rabbits were administrated with drugs for 14 and 28 days and after the drug treatment was stopped for 7 and 40 days.The Hg level in urine was significantly enhanced after the drug withdrawal for 1,40,71 days.However,the liver & kidney indicators were not influenced.Conclusion: The Hg level in rabbit blood and urine was significantly increased after the consecutive administration of double-dose Jiuyi Dan for 1 month.However,the blood Hg level and urine Hg level recover after the drug withdrawal for 71 days and 3 months,respectively.The liver & kidney indicators do not significantly change with the dose. |
| Keywords: | Jiuyi Dan Hg in blood Hg in urine liver & kidney function indicator rabbit external use for 1 month |
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