A micro-PET/CT approach using O-(2-[F]fluoroethyl)-l-tyrosine in an experimental animal model of F98 glioma for BNCT |
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| Authors: | L. Menichetti D. Petroni D. Panetta S. Burchielli Silva Bortolussi M. Matteucci G. Pascali S. Del Turco A. Del Guerra S. Altieri P.A. Salvadori |
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| Affiliation: | aCNR Institute of Clinical Physiology, Pisa, Italy;bFondazione CNR/Regione Toscana G. Monasterio, Pisa, Italy;cDept. Theoretical and Nuclear Physics, University of Pavia, Pavia, Italy;dScuola Superiore Sant'Anna, Pisa, Italy;eDepartment of Physics, University of Pisa, Pisa, Italy |
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| Abstract: | The present study focuses on a micro-PET/CT application to be used for experimental Boron Neutron Capture Therapy (BNCT), which integrates, in the same frame, micro-CT derived anatomy and PET radiotracer distribution. Preliminary results have demonstrated that 18F-fluoroethyl-tyrosine (FET)/PET allows the identification of the extent of cerebral lesions in F98 tumor bearing rat. Neutron autoradiography and α-spectrometry on axial tissues slices confirmed the tumor localization and extraction, after the administration of fructose–boronophenylalanine (BPA). Therefore, FET–PET approach can be used to assess the transport, the net influx, and the accumulation of FET, as an aromatic amino acid analog of BPA, in experimental animal model. Coregistered micro-CT images allowed the accurate morphological localization of the radiotracer distribution and its potential use for experimental BNCT. |
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| Keywords: | [18F]F-BPA [18F]FET Treatment planning BNCT Head and neck cancer Positron emission tomography |
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