Intraductal papillomas of the breast: diagnosis and management of 151 patients |
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Authors: | Richter-Ehrenstein Christiane Tombokan Felicia Fallenberg Eva-Maria Schneider Achim Denkert Carsten |
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Institution: | aDepartment of Gynecology, Interdisciplinary Breast Center, Charité University Medicine Berlin, Germany;bInstitute of Radiology, Charité University Medicine Berlin, Germany;cInstitute of Pathology, Charité University Medicine Berlin, Germany |
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Abstract: | IntroductionThe assessment of papillary lesions continues to be a challenging area in breast radiology and pathology. The management of intraductal papillomas without atypia of the breast remains controversial. The purpose of the present study was to determine diagnostic accuracy of radiographical diagnosis, core biopsy, and surgical excision in papillary breast lesions.Material and methodsBy using files from 1995 to 2010, 151 cases of intraductal papilloma with or without atypia were identified. Patients were stratified as follows: core biopsy followed by surgical excision (n = 61), core biopsy alone (n = 19), and surgical excision alone (n = 71).ResultsThe upstage rate of intraductal papillomas without atypia on core biopsy to atypia or malignancy on excision was 8.9%. Excision specimens revealed intraductal papillomas without atypia in 68 out of 71 cases, and atypical papillomas in 3 cases.ConclusionOur findings suggest that radiographic and histopathological diagnosis of intraductal papillomas show high accuracy and good concordance. In cases where the radiographic diagnosis reveals suspicious lesions core biopsy represents the first choice. |
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Keywords: | Intraductal papilloma Core needle biopsy Surgical excision Breast cancer |
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