深圳市结核分枝杆菌耐药监测疫情趋势分析

目的 监测耐药肺结核的流行情况和趋势，评价本市结核病控制效果。方法 按WHO／IUAT（（结核病耐药指南》的要求对新登记的涂片阳性肺结核病人进行耐药肺结核监测，所选例数不低于全年登记的涂片阳性肺结核病人的40％。结果 监测涂片阳性病例2250例，涂片培养均阳性者2168例；平均耐药率为34．9％，链霉素耐药最高，达24．1％；耐多药率为5．5％，耐药病人主要集中在青壮年。结论 本市结核耐药水平较高，明显受到外来人口的影响，全市推行DOTS策略，是降低区域耐药结核的重要措施。

Research on the current of drug resistance of Mycobacterium tuberculosis in Shenzhen

Objective Researching on the current of drug resistance of mycobacterium tuberculosis by drug resistance monitoring to estimate effect of tuberculosis control.Methods Implement according to the manual of drug resistance monitoring compiled by WHO/IUAT were forllowed.The cases surveilled by drug monitoring were not less than 40% of new smear positive cases per annum.Result There were 2 250 new smear positive cases supervised.2 168 of total cultured were positive.Average rate of drug resistance was 34.9% and the rate of streptomycin drug resistance was the highest (24.1%).Average rate of multi-drug resistance was 5.5%.The most of them were youth and middle age.Conclusion The rate of drug resistance was high because of importing population.Implement DOTS strategy in whole population is very importance to reduce epidemic situation of tuberculosis.