| 二氯胺基酚诱发的染色体畸变及染毒时间对畸变率的影响研究 |
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| 引用本文： | 衡正昌 T.Ong^2. 二氯胺基酚诱发的染色体畸变及染毒时间对畸变率的影响研究[J]. 现代预防医学, 1997, 24(1): 4-7 |
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| 作者姓名： | 衡正昌 T.Ong^2 |
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| 作者单位： | 华西医科大学公共卫生学院 |
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| 摘 要： | ２，４－二氯胺基酚（ＤＣＡＰ）是８３—１除草剂在哺乳动物体内的主要代谢产物。本研究以三种染毒计划观察了ＤＣＡＰ诱发Ｖ７９细胞的染色体畸变。结果表明：ＤＣＡＰ是一种染色体损伤剂，诱发的畸变主要为染色单体断裂和交换；３ｈ染毒和染毒后培养１７ｈ诱发的染色体畸变率最高，２０ｈ染毒观察不到染色体畸变，说明以高浓度短期染毒对高细胞毒性化合物的细胞遗传毒性研究可能是较好的染毒方案。
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| 关 键 词： | 二氯胺基酚 染色体畸变 染毒时间 V79细胞 |
CHROMOSOMAL ABERRATIONS(CA) INDUCED BY DICHLOROAMINOPHENOL AND THE EFFECT OF TREATMENT TIME ON FREQUENCY OF CA.Heng Zhengchang,T.Ong. |
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| School of Public Health,West China University of Medical Sciences,Chengdu ,Sichuan,P.R.C.. CHROMOSOMAL ABERRATIONS(CA) INDUCED BY DICHLOROAMINOPHENOL AND THE EFFECT OF TREATMENT TIME ON FREQUENCY OF CA.Heng Zhengchang,T.Ong.[J]. Modern Preventive Medicine, 1997, 24(1): 4-7 |
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| Authors: | School of Public Health West China University of Medical Sciences Chengdu Sichuan P.R.C. |
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| Affiliation: | School of Public Health,West China University of Medical Sciences,Chengdu 610041,Sichuan,P.R.C. |
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| Abstract: | 2,4 Dichloro 6 aminophenol(DCAP) is a major metabolite of herbicide 83-1.The studies were performed under three treatment conditions to obverse CA induced by DCAP in V79 cells.Results showed that DCAP was clastogen and the aberrations were mainly chromatid breaks and exchanges.The 3h treatment following a 17h post treatment incubation gave rise the highest frequeney of CA,while the 20h treatment did not yield a significant increase of CA.It indicated that short term treatment with higher concentrations was a better treatment protocol for cytogenetic studies of cytotoxic chemicals. |
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| Keywords: | Dichloroaminophenol Chromosomal aberration Treatment time V79 cell |
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