| 上皮钙粘素在胃癌中的表达及意义 |
| |
| 引用本文： | 陈仲敏,钟愉,何常.上皮钙粘素在胃癌中的表达及意义[J].贵阳医学院学报,2002,27(3):217-218. |
| |
| 作者姓名： | 陈仲敏 钟愉 何常 |
| |
| 作者单位： | 1. 贵阳医学院附院内科,贵州贵阳,550004
2. 贵阳医学院病理学教研室,贵州贵阳,550004 |
| |
| 摘 要： | 目的：探讨上皮钙粘素（E－cadherin,E-CD）在慢性胃炎、胃粘膜异型增生及胃癌组织中的表达及与胃癌生物学行为的关系。方法：应用免疫组织化学SP法研究20例慢性胃炎、20例胃粘膜异型增生及50例胃癌组织中E－CD的表达。结果：慢性胃炎、胃粘膜异型增生及胃癌的阳性表达率分别为95．0％（19／20例）、85．0％（17／20例）、42．0％（21／50例）。慢性胃炎及胃粘膜异型增生组的阳性表达率显高于胃癌组（P＜0．01），同时E－CD在胃癌组织中的表达与胃癌的分化程度、淋巴结转移、浸润深度及临床分期等有相关关系（P＜0．05，P＜0．01）。结论：E－CD参与了肿瘤的发生、发展、浸润及转移。
|
| 关 键 词： | 上皮钙粘素 胃肿瘤 胃炎 钙粘着糖蛋白类 免疫组织化学 E－CD |
| 文章编号： | 1000-2707(2002)03-0217-02 |
| 修稿时间： | 2002年4月10日 |
Expression of E-cadherin and Its Significance in Gastric Carcinoma |
| |
| CHEN Zhong min ,ZHONG Yu ,HE Chang.Expression of E-cadherin and Its Significance in Gastric Carcinoma[J].Journal of Guiyang Medical College,2002,27(3):217-218. |
| |
| Authors: | CHEN Zhong min ZHONG Yu HE Chang |
| |
| Institution: | CHEN Zhong min 1,ZHONG Yu 2,HE Chang 2 |
| |
| Abstract: | Objective:To study the expression of E cadherin(E CD) in chronic gastritis(CG), dysplasia(Dys), gastric cancer(GC) and the relationship of E CD expression and significance in GC. Methods: Using immunohistochemistry of SP, we studied the expression of E CD in 20 cases of CG, 20 cases of Dys and 50 cases of GC. Results: The positive rates in CG, Dys ,GC were 95.0%, 85.0%, 42.0%, respectively. The positive rates in CG, Dys were higher than that in GC(P<0.05,P<0.01), and the expression of E CD in GC related to its differentiation, lymph node metastasis, depth of invasion and clinical stage(P<0.01). Conclusion: E CD is involved in the genesis, development, invasion and metastasis of the tumor. |
| |
| Keywords: | stomach neoplasms gastritis cadherins Immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
