依达拉奉对大鼠脑出血后脑水肿及脂质过氧化反应的影响

目的 探讨依达拉奉对脑出血（ICH）后脑组织氧化损害的保护作用.方法 105只SD大鼠随机分为依达拉奉治疗组、ICH组和假手术组,每组35只.术后每组分7个时点（各5只）.立体定向自体血注入尾状核建立ICH模型;观察各组各时点血肿周围脑组织超氧化物歧化酶（SOD）活力和丙二醛（MDA）含量.结果 ICH组各时点SOD活性明显低于假手术组,而MDA含量明显高于假手术组,ICH组各时点含水量与SOD活力呈明显负相关,与MDA含量呈明显正相关.依达拉奉组SOD活力显著高于ICH组,12～96h时点MDA明显低于ICH组,依达拉奉组含水量与SOD活力呈显著负相关,与MDA呈显著正相关.结论 依达拉奉使脑出血氧化损害明显减轻,抗自由基药物可能是治疗脑出血后脑水肿的一个重要途径.

Effect of edaravone on cerebral edema and lipid peroxidation in rat brain after intracerebral hemorrhage

Objective To explore the protective effect of edaravone on oxidatire damage of the brain after intracerebral hemorrhage(ICH).Methods In this study,105 SD rats were divided into edaravone group,lCH group and sham operation group.We induced intracerebral hemorrhage in rats by injecting autologous blood into the left caudate.The activity of SOD and the contents of MDA were detected.Results Compared with sham operation group,in ICH group the activity of SOD was obviously decreased and the content of MDA was significantly increased.Water contents were obviously positively correlated with MDA,while they were significantly negatively correlated with SOD.Compared with ICH control group,in Edaravone group MDA at 12-96h was obviously lower and SOD was higher.Water contents were positively correlated with MDA,while they were negatively correlated with SOD.Conclusion Treatment with Edaravone in a rat model of intracerebral hemorrhage reduced obviously oxidation damage.The new anti-free radicals drug may play an important role in treating brain edema after intracerebral hemorrhage.