Loss of surface IgD by human B lymphocytes during polyclonal activation. |
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Authors: | J L Preudhomme |
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Abstract: | Surface and cytoplasmic immunoglobulins were studied by direct immunofluorescence in pokeweed mitogen-stimulated cultures of human blood lymphocytes. The results compared to those of studies of unstimulated cultures and of fresh normal lymphocytes showed a striking decrease in surface IgD during terminal maturation of B lymphocytes into plasma cells. The number of cells which expressed IgG Fe receptor also decreased, although to a lesser extent. |
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