三氯生涂层医用聚丙烯抗菌网片的制作和性能研究

目的：探讨三氯生涂层医用抗菌聚丙烯网片的制作，研究其药物的控释性能以及网片上载前后性能。
方法：以三氯生为抗菌剂，乙烯-乙烯醇共聚物为载体，应用溶剂蒸发法，制成三氯生涂层医用抗菌聚丙烯网片。将网片分为A，B，C，D 4组，A，B，C组为三氯生涂层医用抗菌聚丙烯网片实验组，D为对照组。在电镜下观察4组网片的超微结构；测定抗菌网片不同时段的抑菌圈直径；采用浸泡法测定实验前后网片在不同时间段释放药物的抑菌效果；测定实验前后网片在横向和纵向被拉断时所能承受的最大拉力。
结果：实验组网片涂层表面均匀光滑，在生理盐水中能持续释放7 d，在1，3，5，7 d实验组抑菌圈直径明显大于对照组（P＜0.05），两组网片在不同张力下的横向及纵向所能承受的最大拉力无统计学意义。
结论：经溶剂蒸发法制备的三氯生涂层医用抗菌聚丙烯网片具有药物控释性能和明显抗菌性能，而其生物力学性能在实验前后基本不变，为临床处理无张力疝修补术后的人工补片感染问题提供一个新的方法和途经。

Preparation of medical polypropylene anti-bacterial mesh coated with triclosan and detection of its nature

Objective:To explore the production of medical polypropylene anti-bacterial mesh coated with triclosan，and study the properties of its controlled-release drugs, as well as the efficiency of the mesh coated with triclosan. Methods :A medical polypropylene anti-bacterial mesh coated with triclosan was produced by the method of solvent evaporation,with triclosan as antibacterial agent and ethylene-vinyl alcohol copolymer as carrier. The meshes were divided into four groups: A,B,C and D. The meshes in A,B and C (experimental) groups were coated with triclosan, and D group was control group. The ultrastructure of meshes of the 4 groups was observed under electron microscope.The slip diffusion method was used to observe the diameter of bacteriostasis-rings in different time periods. At the same time, we observed the maximum tensile strength of the mesh in transverse and longitudinal axis when they were pulled off before and after the experiment. Results:The surfaces of B group were uniform and smooth, and the coating could continuously release drugs during 7 days in sodium chloride. The diameter of bacteriostasis-rings in B group was significantly larger than that in control group (P<0.05) at 1d、3d、5d and 7d,but the maximum tensile strength of the meshes in transverse and longitudinal axis was not sigmificantly changed in the two groups. Conclusions:The medical polypropylene anti-bacterial mesh coated with triclosan by the method of solvent evaporation has the properties of controlled-release drugs and obvious anti-bacterial function. The biomechanics of the mesh remained the same essentially before and after the experiment. The study provides a new method and route for the clinical management of prosthetic patch infection after tension-free hernia repair.