Time-dose relationships in combined bleomycin treatment and radiotherapy |
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| Authors: | S J Jorgensen |
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| Affiliation: | 1. Duke University Medical Center, Durham, NC;2. Duke Clinical Research Institute, Durham, NC;3. Division of Cardiology, University of California, Los Angeles, Los Angeles, CA;4. Lankenau Institute for Medical Research, Wynnewood, PA;5. Janssen Scientific Affairs, Raritan, NJ;6. Harvard Medical School, Massachusetts General Hospital, Boston, MA;7. Lenox Hill Hospital, New York, NY;8. Mayo Clinic, Rochester, MN;9. Department of Medicine, Stanford University School of Medicine, Palo Alto, CA;10. Boston University School of Medicine, Boston, MA;11. Kaiser Permanente, Oakland, CA |
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| Abstract: | The biological effect of bleomycin resembles that of X-ray irradiation indicating that the combination of bleomycin and radiotherapy may have a synergistic effect.In cyclic bleomycin treatment of a murine carcinoma it was found that intermittent bleomycin treatment and radiotherapy results in a simple addition of the therapeutic effects of the two different treatments. Simultaneous treatment, however, results in a synergistic intensifying of the therapeutic effect.The toxicity of bleomycin was found to be unaltered by the regional application of X-ray irradiation. |
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