| 脂肪组织巨噬细胞浸润与胰岛素抵抗 |
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| 引用本文： | 郭彩红,袁莉.脂肪组织巨噬细胞浸润与胰岛素抵抗[J].国际内分泌代谢杂志,2008,28(5). |
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| 作者姓名： | 郭彩红 袁莉 |
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| 作者单位： | 1. 北京航天总医院
2. 华中科技大学同济医学院附属协和医院内分泌科,武汉,430022 |
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| 摘 要： | 肥胖是一种低度炎性反应状态.近年来发现肥胖个体脂肪组织中巨噬细胞的浸润显著增加,并有研究表明脂肪组织的炎性反应因子主要由浸润的巨噬细胞分泌.目前对脂肪组织巨噬细胞的来源以及影响其浸润的因素还有争论.研究发现,巨噬细胞可以通过抑制脂肪细胞分化,增加炎性反应因子的表达等导致胰岛素抵抗的发生、发展.
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| 关 键 词： | 巨噬细胞 脂肪组织 炎症 肥胖 胰岛素抵抗 |
Macrophage infiltration in adipose tissue and insulin resistance |
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| GUO Cai-hong,YUAN Li.Macrophage infiltration in adipose tissue and insulin resistance[J].International JOurnal of Endocrinology and Metabolism,2008,28(5). |
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| Authors: | GUO Cai-hong YUAN Li |
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| Abstract: | Obesity is a chronic state of inflammation.In recent years,researches have showed that macrophage infiltration of adipose tissue in obese individuals was increased and macrophages were the primary source of many inflammatory factors.Currently,itis not clear what causes increased macrophage infiltration of adipose tissue in obese individuals.The present researches showed that macrophages can inhibit the differentiation of adipocyte,and increase the expression of the inflammatory cytokines.The macrophage infiltration of adipose tissue played an important role in the development of insulin resistance. |
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| Keywords: | Macrophage Adipose tissue Inflammation Obesity Insulin resistance |
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