庆大霉素给药方案与其毒性关系的病理学研究

本文应用光镜及扫描电子显微镜对庆大霉素给药方案与其耳、肾毒性关系进行研究,显示庆大霉素所致耳蜗病变具有一定的特点及规律,其程度主要取决于用药剂量的大小,在剂量相同条件下与给药方案无关。其肾脏损害在剂量一定条件下,1日分次给药较1日1次给药程度明显加重,即血中长时期维持一定的药物浓度较1次高峰浓度的肾毒性更为明显。

Pathological Study on Correlation between Gentamicin Giving-programmes and Toxicity of Gentamicin

In order to study the correlation between the toxicity of gentamicin (G. M.) and G, M. -giving-programmes, 53 healthy adult male guinea-pigs with normal auricle reflex weighing 250-450g were divided into 5 groups. Light microscopy and electron microscopy were carried out and changes of Corti's organ in each group were compared. The result showed that there are no obvious difference in the quality and quantity between group A_1 and A_2, B_1 and B_2. But the pathological changes in group A_1 and A_2 are more severe than group B_1 and B_2. This proved that the ototoxicity of G. M. had no relation to programme of given drug, but mainly depended on total dosage. Observing and comparing the pathological changes in kidney showed that group A_2 is more severe than group A_1, B_2 is more severe than B_1. This proved that the nephrotoxicity of G. M. one day dosage given dividedly was more severe than one day dosage given once.