| 增敏化合物丁胱亚磺酰亚胺对离体细胞的毒性作用 |
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| 引用本文： | 金一尊,丁立,沈芝芬,蔡荣妹,许立明,周建议,杨家宽.增敏化合物丁胱亚磺酰亚胺对离体细胞的毒性作用[J].复旦学报(医学版),1991(4). |
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| 作者姓名： | 金一尊 丁立 沈芝芬 蔡荣妹 许立明 周建议 杨家宽 |
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| 作者单位： | 上海医科大学放射医学研究所8室
(金一尊，丁立，沈芝芬，蔡荣妹，许立明，周建议)，上海医科大学放射医学研究所8室(杨家宽) |
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| 摘 要： | 本文报道国内首次合成的新增敏化合物——丁胱亚磺酰亚胺(buthioine sulfoxi-mine,简称BSO)对离体中国仓鼠V79-379A细胞在各种不同条件下的细胞毒性作用。实验结果表明:BSO在离体实验条件下对细胞的毒性作用较小;当它与双功能性的辐射增敏剂RSU-1069合用时,可明显地增加RSU-1069的细胞毒性作用,这在肿瘤放射治疗与化学药物治疗中有重要的意义。
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| 关 键 词： | 丁胱亚磺酰亚胺(BSO) 增敏化合物 辐射增敏剂 离体实验 细胞毒性 |
IN VITRO CYTOTOXICITY OF SENSITIZER BSO |
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| Jin Yizun,Ding Li,Shen Zhifen,Cai Rongmei,Xu Liming Zhou Jianyi,Yang Jiakuan.IN VITRO CYTOTOXICITY OF SENSITIZER BSO[J].Fudan University Journal of Medical Sciences,1991(4). |
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| Authors: | Jin Yizun Ding Li Shen Zhifen Cai Rongmei Xu Liming Zhou Jianyi Yang Jiakuan |
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| Abstract: | BSO (buthionine sulfoximine) is a new potential sensitizer synthesised in our laboratory. In this paper, we report the experimental results of BSO cytotoxicity on in vitro cultured Chinese hamster V79-379A cells. It is shown in the experiments that the cytotoxicity of BSO itself is low. However, incubation with BSO for longer than 48 hours produced significant cybotoxicity. The cytotoxicity of radiosensitizer RSU-1069 was enhanced when it was combined with BSO. That will be a highly beneficial in cancer radiotherapy and chemotherapy. |
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| Keywords: | buthionine sulfoximine (BSO) sensitivity compound in vitro radiosensitizer cytotoxicity |
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