| 采用基因配型行同种异体肾移植术 |
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| 引用本文： | 高佃军,栾志敏,刘海涛,李春龙,郭振家,郭民. 采用基因配型行同种异体肾移植术[J]. 潍坊医学院学报, 2003, 25(5): 332-334 |
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| 作者姓名： | 高佃军 栾志敏 刘海涛 李春龙 郭振家 郭民 |
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| 作者单位： | 1. 潍坊医学院附属医院泌尿外科,山东,潍坊,261031
2. 潍坊医学院附属医院血液净化中心 |
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| 摘 要： | 目的 探讨基因配型技术在同种异体肾移植中的应用。方法采用顺序特异引物聚合酶链反应法(PCR-SSP)分别进行供、受体的基因分型，为3例配型适当的终末性肾病患者行同种异体肾移植术，并观察其术后肾功能恢复情况。结果所有接受肾移植的患者于术后2d肾功能恢复至正常水平，无急性和超急性排异发生。随访11-15个月，各项检查指标均正常。结论 基因配型的准确率较之传统的血清学配型显著增加，显著提高同种异体肾移植的成功率。
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| 关 键 词： | 肾移植 组织配型 人白细胞抗原 聚合酶链反应 分子生物学 |
| 文章编号： | 1004-3101(2003)05-0332-03 |
| 修稿时间： | 2003-02-18 |
Homologous Donor Renal Transplantation with Gene Type Matching |
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| GAO Dian-jun,LUAN Zhi-min,LIU Hai-tao,LI Chun-long,GUO Zhen-jia,Guo Min. Homologous Donor Renal Transplantation with Gene Type Matching[J]. Journal of Weifang Medical College, 2003, 25(5): 332-334 |
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| Authors: | GAO Dian-jun LUAN Zhi-min LIU Hai-tao LI Chun-long GUO Zhen-jia Guo Min |
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| Abstract: | Objective To investigate the application of gene type-macthing in homologous donor renal transplantation.Methods The technique Polymerase Chain Reaction with Sequence-Specific Primers(PCR with SSP),to establish the gene type analysis for three patients with end stage renal disease and their donors,and the patients were given the homologous rehal transplantation.Results All the 3 patients recovered to normal condition in renal function within 2 days.Neither hyperacute rejection nor acute rejection was observed.And the patients' condition have been kept stable for the past 11 to 15 months.Conclusion Gene type-matching provides higher accurate rates than hereditary characteristic,and therefore elevate successful rates. |
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| Keywords: | Renal transplantation Tissue type matching HLA PCR Molecular biology |
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