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Tracking evolution of BRCA1-associated breast cancer |
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| Authors: | Jonkers Jos |
| Affiliation: | Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. j.jonkers@nki.nl |
| Abstract: | Single-cell profiling and computational identification of evolutionary paths to BRCA1-associated tumorigenesis predict that PTEN loss and TP53 mutation precede loss of wild-type BRCA1 in basal-like and luminal tumors, respectively. |
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