| 非离子型X线造影剂碘佛醇的合成 |
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| 引用本文： | 罗世能,邹霈,刘娅灵,谢敏浩,何拥军,杨正. 非离子型X线造影剂碘佛醇的合成[J]. 中国新药杂志, 2004, 13(4): 338-340 |
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| 作者姓名： | 罗世能 邹霈 刘娅灵 谢敏浩 何拥军 杨正 |
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| 作者单位： | 江苏省原子医学研究所,无锡,214063 |
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| 基金项目： | 江苏省科技厅科研项目，江苏省卫生厅科研项目 |
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| 摘 要： | 目的:合成非离子型X线造影剂碘佛醇.方法:以自制的5-氨基-N,N'-双(2,3-二羟丙基)-2,4,6-三碘-1,3-苯二甲酰胺为原料,经氯酰化、水解和氮烷基化反应制得碘佛椁粗品;碘佛醇粗品的纯化分别采用甲醇、732和717树脂处理,再用丁醇重结晶.结果:产品经元素分析、红外光谱、核磁共振谱和质谱鉴定与碘佛醇结构一致.结论:该方法操作简便,适于工业化生产.
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| 关 键 词： | 非离子型X线造影剂 碘佛醇 合成 |
| 文章编号： | 1003-3734(2004)04-0338-03 |
Synthesis of ioversol,a non-ionic x-ray contrast agent |
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| LUO Shi-neng,ZOU Pei,LIU Ya-ling,XIE Min-hao,HE Yong-jun,YANG Zheng. Synthesis of ioversol,a non-ionic x-ray contrast agent[J]. Chinese Journal of New Drugs, 2004, 13(4): 338-340 |
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| Authors: | LUO Shi-neng ZOU Pei LIU Ya-ling XIE Min-hao HE Yong-jun YANG Zheng |
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| Abstract: | Objective:To synthesize ioversol,a non-ionic x-ray contrast agent. Methods: loversol was synthesized by choloracetylation, dechlorination, and alkylation of 5-amino-N,N '-bis(2,3-dihy-droxypropyl)-2,4,6-triiodoisophthalamide.The crude product was treated with methanol,732 and 717 resins successionally and purified by recrystallization from butanol. Results: That the structure of the product obtained by the process was confirmed by IR,1H-NMR,13CNMR,MS (FAB) and elemental analysis. Conclusion: A simple and convenient method for synthesis of ioversol is provided and it is suitable for pharmaceutical industry. |
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| Keywords: | non-ionic x-ray contrast agent ioversol synthesis |
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