2型糖尿病亚临床大血管病变患者的血清炎症因子变化

目的:分析有亚临床大血管病变的2型糖尿病患者的血清超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)变化及其与胰岛素抵抗的相关性。方法:检测199例无临床大血管病变的2型糖尿病患者的空腹血糖(FPG)、空腹胰岛素(FIns)、糖化血红蛋白(HbA1c)、稳态模型胰岛素抵抗指数(HOMA-IR)、hs-CRP、IL-6、TNF-α水平,并测量这些患者的颈动脉内膜中层厚度(IMT),将IMT≥0.9mm分为亚临床大血管病变组(A组),IMT<0.9mm为无大血管病变组(B组)。结果:A组的FPG、HOMA-IR、hs-CRP、IL-6均高于B组(P<0.05);A组的HOMA-IR与hs-CRP、IL-6呈正相关(P<0.05)。结论:hs-CRP、IL-6可能是2型糖尿病亚临床大血管病变患者的危险因素。

Changes of serum inflammatory factors in type 2 diabetic patients with subclinical large vessel disease

Objective To analyze the changes and correlations between serum high sensitivity C-reactive protein（hs- CRP）, interleukin-6 （IL-6）, tumor necrosis factor-α（TNF-α insulin resistance and subclinical large vessel disease in type 2 diabetic patients. Methods Levels of fasting plasma glucose （FPG）, fasting insulin （Fins）, glycosylated hemoglobin Alc （HbAlc）, homeostasis model assessement insulin resistance index （HOMA-IR）, hs-CRP, IL-6 and TNF-α, were determined and carotid intima-media thickness （IMT） was measured in type 2 diabetic patients （n=199） with no clinical large vessel disease. If the IMT was equal or greater than 0.9 mm, the patients were categorized into group with subclinical large vessel disease （group A）, and those less than 0.9 mm were categorized into group with no large vessel disease （group B）. Results The mean levels of FPG, HOMA-IR, hs-CRP and IL-6 in group A were higher than that in group B （P〈0.05）. The levels of hs-CRP and IL-6 were positively correlated with the changes of HOMA-IR in group A （P〈0.05）. Conclusions Levels of hs- CRP and IL-6 may be the risk factors of subclinical large vessel disease in type 2 diabetic patients.