胃癌及癌前病变组织中雌激素受体和P21ras的表达及意义

目的 探讨雌激素受体（ＥＲ）和ｒａｓ原癌基因蛋白－Ｐ２ｒａｓ的表达在胃癌发生、发展中的作用及与胃癌生物学行为的关系。方法 采用免疫组化ＳＰ法。结果 ＥＲ在慢性浅表性胃炎（２０例）、异型增生（２１例）中均为阴性，胃癌（４０例）的表达阳性率为４０％，三组比较有显著性差异（Ｉ〈０．０５）。Ｐ２１＾ｒａｓ在慢性浅表性胃炎、异型增生、胃癌的表达阳性率分别为１０％、２３．８％、４７．５％，三组比较差异有显著性

Expressions and significance of estrogen receptor and P21ras in gastric carcinoma and precancerous lesion tissues

Objective To study the relationship and significance between expression of estrogen receptor (ER) or p21ras and gastric cancer or precancerous lesion. Methods Expressions of ER and P21ras were examined by SP immunohistochemistry. Results Expression of ER was negative in 20 chronic superficial gastritis and 21 dysplasia, and the positive rate in gastric cancer was 40%. Positive P21ras expression of gastric cancer was observed in 47.5% and it was significantly higher than chronic superficial gastritis (10%) and dysplasia (23.8%) (P<0.05). The positive rates of ER and P21ras in advanced gastric carcinomas and the group with metastasis were significanly higher than those in early gastric carcinomas and the group without metastasis (P<0.05). Conclusion ER and P21 ras may play an important role in the process of carcinogenesis of gastric mucosa and be used as useful markers for the assessment of biological behavior of gastric carcinoma.