Putative skin-protective formulations in preventing and/or inhibiting experimentally-produced irritant and allergic contact dermatitis |
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| Authors: | Hongbo Zhai Paul Willard Howard I. Maibach |
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| Affiliation: | Department of Dermatology, University of California, School of Medicine, San Francisco 94143-0989, USA. |
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| Abstract: | The effectiveness of skin protective formulations was evaluated in a previously-described in vivo human model. All formulations failed to inhibit ammonium hydroxide and urea irritation. Only paraffin wax in cetyl alcohol statistically (p<0.01) reduced Rhus allergic contact dermatitis. 3 commercial formulations markedly (p<0.001) suppressed sodium lauryl sulfate irritation. Paraffin wax in cetyl alcohol was quantitatively the most effective formulation. These results suggest that some formulations may provide protective effects against certain, but not all, irritants or allergens. |
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| Keywords: | barrier creams irritation sodium lauryl sulfate (SLS) urea Rhus ammonium hydroxide (NH4OH) irritant contact dermatitis allergic contact dermatitis prevention |
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