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Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation |
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| Authors: | Cristina P. R. Xavier Cristovao F. Lima Mikkel Rohde Cristina Pereira-Wilson |
| Affiliation: | (1) CBMA—Centre of Molecular and Environmental Biology, Department of Biology, School of Sciences, University of Minho, 4710-057 Braga, Portugal;(2) CITAB—Centre for the Research and Technology of Agro-Environmental and Biological Sciences, Department of Biology, School of Sciences, University of Minho, 4710-057 Braga, Portugal;(3) Apoptosis Department, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark; |
| Abstract: | PurposeColorectal tumors (CRC) with microsatellite instability (MSI) show resistance to chemotherapy with 5-fluorouracil (5-FU), the most widely used pharmacological drug for CRC treatment. The aims of this study were to test the ability of quercetin (Q) and luteolin (L) to increase the sensitivity of MSI CRC cells to 5-FU and characterize the dependence of the effects on cells’ p53 status. |
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