生活事件在2型糖尿病发病中作用的追踪研究

目的 :探讨紧张性生活事件在糖尿病发生中的作用。方法 :以 139例糖耐量低减者与 12 1例糖耐量正常者为研究对象 ,平均年龄为 5 7.34± 9.18岁 ,体重指数为 2 3.92± 2 .83,进行为期四年 (3次 )的追踪调查研究。每次均进行口服葡萄糖耐量试验 ,测餐前、餐后血糖 ,进行生活事件测评。结果 :糖尿病发病者在追踪期间所经历的生活事件明显多于未发病者 ,且在某些类别事件上有显著性差异 (P <0 .0 5 ) ,如第二次追踪中的环境问题 ,第三次追踪中的家庭与婚姻问题 ,前两年半时间经历的工作与经济问题及生活事件总频数等 ;生活事件条目分析发现 ,在子女管教困难、家庭主要成员遭意外事故、本人生活习惯改变、本人工作中受批评等 9个项目均值发病者明显高于未发病者。结论 :紧张性生活事件在糖尿病的发生过程中具有重要作用

The Role of Life Events in the Onset of Type 2 Diabetes Mellitus: The Outcomes of Four-year Follow-up Survey

Objective: To explore the role of life events in the occurrence of type 2 diabetes mellitus.Methods: A total of 139 subjects with impaired glucose tolerance(IGT) and 121 subjects with normal glucose tolerance were followed up during 4 years. The blood glucose was tested by oral glucose tolerance test(OGTT). The life events were evaluated during follow-up survey. Results: The frequency and severity of life events of type 2 diabetes were higher than that of non-diabetic control subjects ,such as family stressors, environmental stressors, marital problems et al. The frequency of nine items of life events in type 2 diabetes mellitus was significantly higher than that of control subjects . Conclusion:Stressful life events played a important role in onset of type 2 diabetes mellitus.