含氟牙膏用量对学龄前儿童氟摄入影响的研究

目的 观察含氟牙膏（1000μg/g)不同使用量对学龄前儿童氟化物摄入量的影响。探索学龄前儿童使用含氟牙膏较为合理，安全的用量。方法 采用离子选择性氟电极，测定3个年龄组使用的不同用量含氟牙膏后24h尿氟排泄量，并以使用含氟牙膏前尿氟排泄量作为自身对照。结果 含氟牙膏用量及年龄对学龄前儿童24h尿氟排泄均有显著影响，经SPSS统计轮换民统计有显著差异。结论 学龄前儿童刷牙时因误咽部分含氟牙膏引起氟化物摄入增加，6岁以下的儿童，要减少含氟牙膏的使用量，每次用量不宜超过豌豆大小（约0.25g)。

Effects of Different Quantity of Fluoride Toothpaste on Fluoride Intake by Preschool Children

OBJECTIVE: This study was to investigate the influence of different quantity of fluoride toothpaste(1000 microg/g)on the intake level of fluoride among three children age groups of preschool children,to explore the rational and security quantity of fluoride toothpaste in preschool children. METHODS: Urinary fluoride excretion of 24-hour urinary samples was measured by fluoride ion electrode among three age groups of preschool children,serving 24-hour urinary fluoride excretion before using fluoride toothpaste as self-control. RESULTS: There were statistically significant differences in 24-hour urinary fluoride excretion among four different quantity toothpastes (P<0.01),and among three age groups (P<0.05). CONCLUSION: Fluoride intake level was influenced by the accidental swallowing of fluoride toothpaste among preschool children.So children under 6-year-old should decrease quantity of fluoride toothpaste,no more than a small pea (about 0.25g).