Analysis of creams |
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| Authors: | F J Van De Vaart A Hulshoff A W M Indemans |
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| Institution: | 1. Laboratory of the Dutch Pharmacists, Alexanderstraat 11, 2514, JL The Hague, The Netherlands
2. Pharmaceutical Laboratory, Department of Analytical Pharmacy, University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands
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| Abstract: | The possibilities for the determination of active components in creams by acid-base titrations in non-aqueous solvents were investigated. Interference by cream-base components with the titration of weak organic bases and their halides with perchloric acid in acetic acid, and with the titration of weak acids with tetrabutylammonium hydroxide in N,N-dimethylformamide were studied. It appeared to be possible to determine alkaloid halides, salicylic acid, hexachlorophene and methyl salicylate without previous clean-up of the cream samples. |
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