| iNOS基因微卫星多态性与中国汉族人群糖尿病肾病相关 |
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| 引用本文： | 张政,彭惠民,张素华,郭风劲,晏宁. iNOS基因微卫星多态性与中国汉族人群糖尿病肾病相关[J]. 中华内分泌代谢杂志, 2004, 20(6): 527-528 |
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| 作者姓名： | 张政 彭惠民 张素华 郭风劲 晏宁 |
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| 作者单位： | 1. 400016,重庆医科大学生物学教研室
2. 重庆医科大学附属第一医院内分泌科 |
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| 基金项目： | 重庆市教委科学研究资助项目 (1 999 50 ) |
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| 摘 要： | 诱导型一氧化氮合酶 (iNOS)基因 (CCTTT) 14 等位基因频率在糖尿病肾病组 (0 .0 44 )显著低于糖尿病无肾病组 (0 .170 ,P <0 .0 1)和对照组 (0 .14 3 ,P <0 .0 5 ) ,提示iNOS基因 (CCTTT) n 微卫星多态性与中国汉族 2型糖尿病肾病有关。
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| 关 键 词： | 糖尿病 2型 糖尿病肾病 一氧化氮合酶 |
| 修稿时间： | 2003-08-04 |
Association of ( CCTTT)n microsatellite polymorphism of iNOS gene with diabetic nephropathy in Chinese Hans |
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| ZHANG Zheng ,PENG Hui-min,ZHANG Su-hua,GUO Feng-jin,YAN Ning. Association of ( CCTTT)n microsatellite polymorphism of iNOS gene with diabetic nephropathy in Chinese Hans[J]. Chinese Journal of Endocrinology and Metabolism, 2004, 20(6): 527-528 |
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| Authors: | ZHANG Zheng PENG Hui-min ZHANG Su-hua GUO Feng-jin YAN Ning |
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| Affiliation: | ZHANG Zheng *,PENG Hui-min,ZHANG Su-hua,GUO Feng-jin,YAN Ning. *Department of Biology,Chongqing University of Medical Sciences,Chongqing 400016 |
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| Abstract: | The frequency of inducible nitric oxide synthase (iNOS) gene (CCTTT) 14 allele was significantly lower in diabetic nephropathy group (0.044) than that in diabetics without nephropathy (0.170, P<0.01) and normal control group (0.143, P<0.05), suggesting that (CCTTT) n polymorphism of iNOS gene is related to diabetic nephropathy of type 2 diabetes mellitus in Chinese Hans. |
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| Keywords: | Diabetes mellitus type 2 Diabetic nephropathies Nitric-oxide synthase |
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