| VEGF-C表达和微淋巴管密度与胃癌淋巴转移的关系及意义 |
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| 引用本文： | 罗祥东,赵晶,辛彦,达春丽,肖玉平. VEGF-C表达和微淋巴管密度与胃癌淋巴转移的关系及意义[J]. 解剖科学进展, 2009, 15(1): 6-9 |
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| 作者姓名： | 罗祥东 赵晶 辛彦 达春丽 肖玉平 |
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| 作者单位： | 中国医科大学,附属第一医院肿瘤研究所第四研究室,普通外科研究所肿瘤病理研究室,辽宁,沈阳,110001 |
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| 基金项目： | 辽宁省教育厅重点实验室项目，辽宁省优秀人才计划项目 |
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| 摘 要： | 目的探讨胃癌组织血管内皮生长因子C(VEGF-C)表达和微淋巴管密度(MLVD)及两者与胃癌淋巴转移的关系。方法应用免疫组织化学方法检测208例人胃癌组织、40例癌浸润前缘组织及139例人胃正常粘膜组织中VEGF-C、D2-40的表达,对D2-40阳性脉管进行MLVD计数,并结合病理资料进行统计学分析。结果胃癌组织VEGF-C的表达明显高于正常胃粘膜组织(χ2=109.199,P<0.01);胃癌组织中有淋巴结转移(χ2=14.496,P<0.01)或浸润透浆膜(χ2=11.586,P<0.01)组VEGF-C表达水平分别较无转移或浸润未及浆膜组增高。癌浸润前缘组织中MLVD(18.36±15.60个/mm2)明显高于胃癌组(9.41±9.32个/mm2,t=-3.681,P<0.01)和胃正常粘膜组织(7.70±7.69个/mm2,t=-4.180,P<0.01);胃癌淋巴结转移组MLVD(9.81±9.97个/mm2)高于无转移组(6.41±7.85个/mm2,t=2.516,P<0.01),而在浸润透浆膜组(11.20±10.55个/mm2)和未及浆膜组(8.54±9.36个/mm2)MLVD无差别(t=1.467,P=0.472)。另外,在胃癌组织中VEGF-C表达与MLVD呈正相关(F=2.910,P<0.05)。结论VEGF-C在胃癌中的高表达与胃癌浸润深度、淋巴转移密切相关。
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| 关 键 词： | VEGF-C 微淋巴管密度 淋巴转移 胃癌 |
The Correlation of VEGF-C Expression and Microlymphtic Vessel Density with Lymphatic Metastasis in Gastric Carcinoma |
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| LUO Xiang-dong,ZHAO Jing,XIN Yan,DA Chun-li,XIAO Yu-ping. The Correlation of VEGF-C Expression and Microlymphtic Vessel Density with Lymphatic Metastasis in Gastric Carcinoma[J]. Progress of Anatomical Sciences, 2009, 15(1): 6-9 |
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| Authors: | LUO Xiang-dong ZHAO Jing XIN Yan DA Chun-li XIAO Yu-ping |
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| Affiliation: | Fourth Labratory of Cancer Institute;Department of Tumor Pathology of General Surgery Institute;First Hospital of China Medical University;Shenyang 110001 China |
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| Abstract: | Objective To investigate the correlation of the expression of vascular endothelial growth factor-C(VEGF-C)and microlymphatic vessel density(MLVD)with lymphatic metastasis in gastric carcinoma.Methods Immunohistochemistry technique was used to detect the expression of VEGF-C and D2-40 in 208 gastric carcinoma specimens and 40 specimens of edge-invasive gastric carcinoma and 139 normal gastric mucosa.The MLVD was assayed by D2-40 positive vascular count.Results The expression of VEGF-C was significantly highe... |
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| Keywords: | VEGF-C |
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