Fulminant hepatitis in children in Taiwan: the important role of hepatitis B virus |
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| Authors: | M H Chang C Y Lee D S Chen H C Hsu M Y Lai |
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| Affiliation: | 1. Department of Hygiene,, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece;2. 1st Department of Internal Medicine, G. Genimatas GH, Athens, Greece;3. 3rd Internal Medicine Department-Infectious Diseases, Red Cross Hospital, Athens, Greece;4. Medical School, University of Cyprus;5. 5th Department of Medicine and Infectious Diseases, Evaggelismos GH, Athens, Greece;6. 4th Department of Medicine, Attikon GH, Medical School, National and Kapodistrian University of Athens, Athens, Greece;7. 1st Department of Medicine, Laikon GH, Medical School, National and Kapodistrian University of Athens, Athens, Greece;8. Department of Internal Medicine, Tzaneio GH, Piraeus, Greece;9. HIV/AIDS Unit, A. Syngros Hospital of Dermatology and Venereology, Athens, Greece;10. HIV Unit, 2nd Department of Internal Medicine, Hippokration GH, Medical School, National and Kapodistrian University of Athens, Athens, Greece;11. 1st Department of Pathophysiology, Laikon GH, Medical School, National and Kapodistrian University of Athens, Athens, Greece;12. 2nd Department of Internal Medicine, Sismanogleion GH, Athens, Greece;13. Department of Internal Medicine, University GH, Democritus University of Thrace, Alexandroupolis, Greece |
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| Abstract: | In a recent period of 64 months, fulminant hepatitis was diagnosed in 17 children at National Taiwan University Hospital. Eleven patients were younger than 12 months of age. Hepatitis A IgM antibody and delta-antibody were negative in all 17. Eleven (65%) patients had hepatitis B core IgM antibody, fulminant hepatitis B. Two to 5 months before onset of hepatitis. Five of the 11 children had received blood transfusions. Three of the five donors had hepatitis B e antibody (anti-HBe) and were hepatitis B virus DNA-negative hepatitis B surface antigen (HBsAg) carriers; another two were HBsAg negative, screened by a less sensitive reverse passive hemagglutination method. The mothers of all six infants younger than 6 months of age had HBsAg. HBe antigen and antibody were studied in five of these six mothers; all five had anti-HBe. We conclude that hepatitis B virus is the most important cause of fulminant hepatitis in children in Taiwan. |
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