Modification of single sodium channels by the insecticide tetramethrin |
| |
Authors: | Daisuke Yamamoto Fred N Quandt Toshio Narahashi |
| |
Institution: | Department of Pharmacology, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, IL 60611, U.S.A. |
| |
Abstract: | (+)-trans-Tetramethrin, a pyrethroid insecticide, markedly prolongs the open time of single sodium channels recorded by the gigaohm-seal voltage clamp technique in a membrane patch excised from the N1E-115 neuroblastoma cell. Single channel conductance is not altered by tetramethrin. The modification by tetramethrin occurs in an all-or-none manner in a population of sodium channels. The observed tetramethrin-induced modification of single sodium channels is compatible with previous sodium current data from axons. |
| |
Keywords: | sodium channel patch clamp insecticide tetramethrin pyrethroid neuroblastoma |
本文献已被 ScienceDirect 等数据库收录! |