| 抗真菌药物的研究II.C-端含氧代赖氨酸二肽的合成及抗白念珠菌活性 |
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| 引用本文： | 黄嘉鑫,陈岚,奚明磊,林巍,方佩芬,张鸿龙,顾秀玉. 抗真菌药物的研究II.C-端含氧代赖氨酸二肽的合成及抗白念珠菌活性[J]. 药学学报, 1996, 31(1): 24-28 |
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| 作者姓名： | 黄嘉鑫 陈岚 奚明磊 林巍 方佩芬 张鸿龙 顾秀玉 |
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| 作者单位： | 中国科学院上海药物研究所，上海 200031 |
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| 摘 要： | 引用违法传递概念设计合成了11个C-末端含氧代赖氨酸二肽,进行抗深部致病菌-白念珠菌活性试验,体外实验结果显示极强的抑菌活性,MIC在12.5～0.8μg/disk之间,较母体氧化赖氨酸大50～135倍(克分子比。
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| 关 键 词： | 氧代赖氨酸 违法传递 抗真菌 |
| 收稿时间： | 1995-03-01 |
ON ANTIFUNGAL AGENTS Ⅱ.SYNTHESIS AND ANTICANDIDA ALBICANS ACTIVITY OF C-TERMINAL CONTAINING L-4-OXALYSINE DIPEPTIDE |
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| JX Huang,L Chen,ML Xi,W Lin,PF Fang,HL Zhang and XY Gu. ON ANTIFUNGAL AGENTS Ⅱ.SYNTHESIS AND ANTICANDIDA ALBICANS ACTIVITY OF C-TERMINAL CONTAINING L-4-OXALYSINE DIPEPTIDE[J]. Acta pharmaceutica Sinica, 1996, 31(1): 24-28 |
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| Authors: | JX Huang L Chen ML Xi W Lin PF Fang HL Zhang XY Gu |
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| Abstract: | In order to improve the antifungal effect and the utilitv of L-4-OXalysine(designated as I-677)against clinical pathogen candida albicans,eleven dipeptides with I-677 as C-terminus were designed and synthesized according to the concept of”Illicit Transport“and peptidetransport specifities of C.albicans Anti-C.albicans test in irtro showed that these dipeptides have higheractivitv determined as molar minimum inhibitory concentrations(molar MIC)than that of free I-677by 50～135 fold(as molar MIC)and 31～62 fold(as weight MIC), but less than the N-terminalcontaining I-677 peptides. Mixed anhydride methed was used for the peptide synthesis and the MIC were determined by diskdiffusion assay. |
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| Keywords: | Illicit transport Antifungal L-4-oxalysine(I-677) |
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