针药结合治疗帕金森病合并膀胱过度活动症

目的:验证小剂量托特罗定结合电针治疗帕金森病(PD)合并膀胱过度活动症(OAB)的疗效。方法:将60例PD合并OAB患者随机分为针药组和西药组,每组30例。两组基础美多巴治疗量一致,均停用安坦等抗胆碱药物,针药组口服托特罗定1mg,每日2次,结合电针百会、四神聪、印堂,每日1次;西药组口服托特罗定2mg,每日2次。治疗6周后,观察两组治疗前后排尿变化、帕金森病综合量表(UPDRSⅢ)评分,并记录两组不良反应发生情况。结果:两组治疗后24h平均排尿次数、24h平均尿失禁次数、平均每次尿量均明显改善(均P<0.01),且针药组的改善程度优于西药组(均P<0.05);针药组治疗后UPDRSⅢ评分明显降低(P<0.05),且明显低于西药组(P<0.05);针药组不良反应明显少于西药组。结论:小剂量托特罗定结合电针治疗PD合并OAB疗效优于口服全量托特罗定,不良反应少,而且可改善PD患者的的运动症状。

Parkinson's disease combined with overactive bladder syndrome treated with acupuncture and medication

Objective To evaluate the therapeutic effect of Parkinson’s disease combined with overactive bladder syndrome(OAB) treated with combined therapy of oral administration of Tolterodine with low dose and electroacupuncture.Methods Sixty cases of Parkinson’s disease combined with OAB were randomly divided into a combined acupuncture and medication group(group A) and a medication group(group B),30 cases in each group.In both groups,Madopar basic doses were same,and anticholinergic agents such as Artane were stopped.In group A,Tolterodine was orally taken for 1 mg,twice a day;Baihui(GV 20),Sishengcong(EX-HN 1) and Yintang(EX-HN 3) were punctured with electroacupuncture,once a day.In group B,Tolterodine was orally taken for 2 mg,twice a day.After 6 weeks,the changes of urination and UPDRSⅢ scores were observed,and the adverse reactions were recorded in both groups.Results After treatment,the frequency of average urination of 24 hours,frequency of incontinence of 24 hours and average urine volume at a time were obviously improved(all P<0.01),of which,the above items in group A were superior to those in group B(all P<0.05);the UPDRSⅢ score in group A was superior to that in group B(P<0.05).The adverse reactions in group A were less than those in group B.Conclusion The therapeutic effect of Parkinson’s disease combined with OAB treated with combined therapy of Tolterodine with low dose and electroacupuncture is superior to that of complete dose of Tolterodine with oral administration,with less adverse reactions.And it also can improve the motor symptom of Parkinson’s disease patients.